研究論文(査読付)

    1. Goto-Inoue N*, Morisasa M, Kimura K, Mori T.
      Novel approach to enhance sensitivity while retaining morphology in fragile tissue sections for mass spectrometry imaging J Mass Spec. 2020 in press
    2. Sanoh S, Hanada H, Kashiwagi K, Mori T, Goto-Inoue N, Suzuki K-T, Mori J, Nakamura N, Yamamoto T, Kitamura S, Kotake Y, Sugihara K, Ohta S, Kashiwagi A.
      Amiodarone bioconcentration and suppression of metamorphosis
      in Xenopus. Aquatic Toxicology 2020 228: 105623.
    3. Tamura K+, Goto-Inoue N+, Miyata K, Furuichi Y, Fujii NL, Manabe Y.  +:equall contribution
      Effect of treatment with conditioned media derived from C2C12 myotube on adipogenesis and lipolysis in 3T3-L1 adipocytes. PLoS One. 2020 Aug 5;15(8):e0237095.
    4. Mori T, Kitani Y, Hatakeyama D, Machida K, Goto-Inoue N, Hayakawa S, Yamamoto N, Kashiwagi K, Kashiwagi A.
      Predation threats for a 24-h period activated the extension of axons in the brains of Xenopus tadpoles. Sci Rep. 2020 Jul 16;10(1):11737.
    5. Morisasa M, Kimura K, Sumida M, Fukumoto S, Tamura T, Takeuchi R, Mori T, Goto-Inoue N*.
      Application of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging for Evaluating the Quality of Fish Fillets. Foods. 2020 Apr 1;9(4):402.
    6. Goto-Inoue N, Sato T, Morisasa M, Yamashita H, Maruyama T,  Ikeda H, Sakai R.
      Mass Spectrometry Imaging reveals differential localization of natural sunscreens in the mantle of the giant clam Tridacta cricea. Scientific Reports 2020 10: 656.
    7. Morisasa M, Sato T, Kimura K, Mori T, Goto-Inoue N*
      Application of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging for Food Analysis. Foods. 2019 Dec 2;8(12):633.
    8. Goto-Inoue N*, Sato T, Morisasa M, Igarashi Y, Mori T.
      Characterization of metabolite compositions in wild and farmed Red sea bream (Pagrus major) using mass spectrometry imaging. J Agric Food Chem.  2019 in press.
    9. Morisasa M, Goto-Inoue N*, Sato T, Machida K, Fujitani M, Kishida T, Uchida K, Mori T.
      Investigation of the lipid changes that occure in hypertrophic muscle due to fish protein-feeding using mass spectrometry imaging. J Oleo Sci.  2019;68(2):141-148.
    10. Goto-Inoue N*, Morisasa M, Machida K, Furuichi Y, Fujii NL, Miura S, Mori T.
      Characterization of myofiber type-specific molecules using mass spectrometry imaging. Rapid Communications in Mass Spectrometry  2019 Jan 30;33(2):185-192.
    11. Tanphaichitr N, Kongmanas K, Faul FK, Whitelegge J, Compostella F, Goto-Inoue N, Linton JJ, Doyle B, Oko R, Xu H, Panza L, Saewu A.
      Properties, metabolisms and roles of sulfogalactosylglycerolipid in male reproduction. Progress in Lipid Research 2018 Aug 25;72:18-41.
    12. 古市泰郎, 井上菜穂子, 増田和実
      骨格筋におけるカルニチン:動態解析から見えた新たな役割 体力医学 2018;67(4):261-267.
    13. Goto-Inoue N*, Sato T, Morisasa M, Kashiwagi A, Kashiwagi K, Sugiura Y, Sugiyama E, Suematsu M, Mori T.
      Utilizing mass spectrometry imaging to map the thyroid hormones triiodothyronine and thyroxine in Xenopus tropicalis tadpoles. Anal Bioanal Chem. 2018 Feb;410(4):1333-1340.
    14. Mori T, Yanagisawa Y, Kitani Y, Yamamoto G, Goto-Inoue N, Kimura T, Kashiwagi K, Kashiwagi A.
      The constant threat from a non-native predator increases tail muscle and fast-start swimming performance in Xenopus tadpoles. Biol Open. 2017 Nov 15;6(11):1726-1733.
    15. Nishio T, Kurabe N, Goto-Inoue N, Nakamura T, Sugimura H, Setou M, Maekawa M.
      Immunohistochemical expression analysis of leucine-rich PPR-motif-containing protein (LRPPRC), a candidate colorectal cancer biomarker identified by shotgun proteomics using iTRAQ. Clin Chim Acta. 2017 Aug;471:276-282.
    16. Goto-Inoue N*, Sato T, Fujii NL.
      Visualization of lipids in skeletal muscles by mass spectrometry imaging J Phys Fitness Sports Med. 2017 6 (4): 001-005.
    17. Kawasaki H, Suzuki T, Ito K, Takahara T, Goto-Inoue N, Setou M, Sakata K, Ishida N.
      Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside. Gene. 2017 Mar 7. pii: S0378-1119(17)30139-7.
    18. Goto-Inoue N*, Kashiwagi A, Kashiwagi K, Mori T.
      Metabolomic approach for identifying and visualizing molecular tissue markers in tadpoles of Xenopus tropicalis by mass spectrometry imaging. Biol Open. 2016 Sep 15;5(9):1252-9.
    19. Yoshimura Y, Goto-Inoue N, Moriyama T, Zaima N.
      Significant advancement of mass spectrometry imaging for food chemistry. Food Chem. 2016 Nov 1;210:200-11.
    20. Manabe Y, Ogino S, Ito M, Furuichi Y, Takagi M, Yamada M, Goto-Inoue N, Ono Y, Fujii NL.
      Evaluation of an in vitro muscle contraction model in mouse primary cultured myotubes. Anal Biochem. 2016 Mar 15;497:36-8.
    21. Goto-Inoue N, Tamura K, Motai F, Ito M, Miyata K, Manabe Y, Fujii NL.
      A fragmented form of annexin A1 is secreted from C2C12 myotubes by electric pulse-induced contraction. Mol Cell Biochem. 2016 Jan;411(1-2):173-80.
    22. Senoo N, Miyoshi N, Goto-Inoue N, Minami K, Yoshimura R, Morita A, Sawada N, Matsuda J, Ogawa Y, Setou M, Kamei Y, Miura S.
      PGC-1α-mediated changes in phospholipid profiles of exercise-trained skeletal muscle. J Lipid Res. 2015 Dec; 56(12):2286-96.
    23. Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Sano M, Saito T, Hayasaka T, Goto-Inoue N, Sato K, Kugo H, Moriyama T, Konno H, Setou M, Unno N.
      Imaging Mass Spectrometry Reveals a Unique Distribution of Triglycerides in the Abdominal Aortic Aneurysmal Wall. J Vasc Res. 2015;52(2):127-35.
    24. Tanaka H, Zaima N, Sasaki T, Sano M, Yamamoto N, Saito T, Inuzuka K, Hayasaka T, Goto-Inoue N, Sugiura Y, Sato K, Kugo H, Moriyama T, Konno H, Setou M, Unno N.
      Hypoperfusion of the Adventitial Vasa Vasorum Develops an Abdominal Aortic Aneurysm. PLoS
      One. 2015 Aug 26;10(8):e0134386.
    25. Manabe Y, Takagi M, Nakamura-Yamada M, Goto-Inoue N, Taoka M, Isobe T, Fujii NL.
      Redox proteins are constitutively secreted by skeletal muscle. J Physiol Sci. 2014 Nov;64(6):401-9.
    26. Furuichi Y, Goto-Inoue N*, Manabe Y, Setou M, Masuda K, Fujii NL.
      Imaging mass spectrometry reveals fiber-specific distribution of acetylcarnitine and contraction-induced carnitine dynamics in rat skeletal muscles. Biochim Biophys Acta. 2014 Oct; 1837(10):1699-706.
    27. Zaima N, Goto-Inoue N, Moriyama T.
      Matrix-assisted laser desorption/ionization imaging mass spectrometry: new technology for vascular pathology. J Vasc Res. 2014; 51(2):144-8.
    28. Goto-Inoue N, Yamada K, Inagaki A, Furuichi Y, Ogino S, Manabe Y, Setou M, Fujii NL. Lipidomics analysis revealed the phospholipid compositional changes in muscle by chronic exercise and high-fat diet. Sci Rep. 2013 Nov 20; 3:3267.
    29. Suzuki T, Shimoda M, Ito K, Hanai S, Aizawa H, Kato T, Kawasaki K, Yamaguchi T, Ryoo HD, Goto-Inoue N, Setou M, Tsuji S, Ishida N.
      Expression of human Gaucher disease gene GBA generates neurodevelopmental defects and ER stress in Drosophila eye. PLoS One. 2013 Aug 2; 8(8):e69147.
    30. Nakajima K, Terao M, Takaishi M, Kataoka S, Goto-Inoue N, Setou M, Horie K, Sakamoto F, Ito M, Azukizawa H, Kitaba S, Murota H, Itami S, Katayama I, Takeda J, Sano S.
      Barrier abnormality due to ceramide deficiency leads to psoriasiform inflammation in a mouse model. J Invest Dermatol. 2013 Nov; 133(11):2555-65.
    31. Morita Y, Sakaguchi T, Ikegami K, Goto-Inoue N, Hayasaka T, Hang VT, Tanaka H, Harada T, Shibasaki Y, Suzuki A, Fukumoto K, Inaba K, Murakami M, Setou M, Konno H.
      Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression. J Hepatol. 2013 Aug; 59(2):292-9.
    32. Tanaka H, Zaima N, Sasaki T, Hayasaka T, Goto-Inoue N, Onoue K, Ikegami K, Morita Y, Yamamoto N, Mano Y, Sano M, Saito T, Sato K, Konno H, Setou M, Unno N.
      Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm. PLoS One.
      2013;8(2):e57398.
    33. Goto-Inoue N, Hayasaka T, Zaima N, Nakajima K, Holleran WM, Sano S, Uchida Y, Setou M.
      Imaging mass spectrometry visualizes ceramides and the pathogenesis of dorfman-chanarin syndrome due to ceramide metabolic abnormality in the skin. PLoS One. 2012;7(11):e49519.
    34. Tarutani M, Nakajima K, Uchida Y, Takaishi M, Goto-Inoue N, Ikawa M, Setou M, Kinoshita T, Elias PM, Sano S, Maeda Y.
      GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier. J Invest Dermatol. 2012 Aug;132(8):2019-25.
    35. Chansela P, Goto-Inoue N, Zaima N, Hayasaka T, Sroyraya M, Kornthong N, Engsusophon A, Tamtin M, Chaisri C, Sobhon P, Setou M.
      Composition and localization of lipids in Penaeus merguiensis ovaries during the ovarian maturation cycle as revealed by imaging mass spectrometry. PLoS One. 2012;7(3): e33154.
    36. Goto-Inoue N*, Manabe Y, Miyatake S, Ogino S, Morishita A, Hayasaka T, Masaki N, Setou M, Fujii NL.
      Visualization of dynamic change in contraction-induced lipid composition in mouse skeletal muscle by matrix-assisted laser desorption/ionization imaging mass spectrometry. Anal Bioanal Chem. 2012 Jun;403(7):1863-71.
    37. Koizumi S, Hayasaka T, Goto-Inoue N, Doi K, Setou M, Namba H.
      Imaging mass spectrometry evaluation of the effects of various irrigation fluids in a rat model of postoperative cerebral edema. World Neurosurg. 2012 Jan; 77(1):153-9.
    38. Waki ML, Onoue K, Takahashi T, Goto K, Saito Y, Inami K, Makita I, Angata Y, Suzuki T, Yamashita M, Sato N, Nakamura S, Yuki D, Sugiura Y, Zaima N, Goto-Inoue N, Hayasaka T, Shimomura Y, Setou M.
      Investigation by imaging mass spectrometry of biomarker candidates for aging in the hair cortex. PLoS One. 2011; 6(10):e26721.
    39. Xu H, Kongmanas K, Kadunganattil S, Smith CE, Rupar T, Goto-Inoue N, Hermo L, Faull KF, Tanphaichitr N.
      Arylsulfatase A deficiency causes seminolipid accumulation and a lysosomal storage disorder in Sertoli cells. J Lipid Res. 2011 Dec; 52(12):2187-97.
    40. Zaima N, Sasaki T, Tanaka H, Cheng XW, Onoue K, Hayasaka T, Goto-Inoue N, Enomoto H, Unno N, Kuzuya M, Setou M.
      Imaging mass spectrometry-based histopathologic examination of atherosclerotic lesions. Atherosclerosis. 2011 Aug;217(2):427-32.
    41. Miyamura N, Nakamura T, Goto-Inoue N, Zaima N, Hayasaka T, Yamasaki T, Terai S, Sakaida I, Setou M, Nishina H.
      Imaging mass spectrometry reveals characteristic changes in triglyceride and phospholipid species in regenerating mouse liver. Biochem Biophys Res Commun. 2011 Apr 29;408(1):120-5.
    42. Goto-Inoue N*, Hayasaka T, Zaima N, Setou M.
      Imaging mass spectrometry reveals changes of metabolites distribution in mouse testis during testicular maturation. Surface Interface Anal. 2011 Nov; sia. 3869.
    43. Matsumoto J, Sugiura Y, Yuki D, Hayasaka T, Goto-Inoue N, Zaima N, Kunii Y, Wada A, Yang Q, Nishiura K, Akatsu H, Hori A, Hashizume Y, Yamamoto T, Ikemoto K, Setou M, Niwa S.
      Abnormal phospholipids distribution in the prefrontal cortex from a patient with schizophrenia revealed by matrix-assisted laser desorption/ionization imaging mass spectrometry. Anal Bioanal Chem. 2011 Jun;400(7):1933-43.
    44. Chansela P, Goto-Inoue N, Zaima N, Sroyraya M, Sobhon P, Setou M.
      Visualization of neuropeptides in paraffin-embedded tissue sections of the central nervous system
      in the decapod crustacean, Penaeus monodon, by imaging mass spectrometry. Peptides. 2012
      Mar; 34(1):10-8.
    45. Goto-Inoue N*, Hayasaka T, Zaima N, Setou M.
      Imaging mass spectrometry for lipidomics. Biochim Biophys Acta. 2011 Nov; 1811(11):961-9.
    46. Hayasaka T, Goto-Inoue N, Ushijima M, Yao I, Yuba-Kubo A, Wakui M, Kajihara S, Matsuura M, Setou M.
      Development of imaging mass spectrometry (IMS) dataset extractor software, IMS convolution. Anal Bioanal Chem. 2011 Jul; 401(1):183-93.
    47. Zaima N, Goto-Inoue N, Hayasaka T, Enomoto H, Setou M.
      Authenticity assessment of beef origin by principal component analysis of matrix-assisted laser desorption/ionization mass spectrometric data. Anal Bioanal Chem. 2011 Jun;400(7):1865-71.
    48. Katagiri YU, Sato B, Yamatoya K, Taki T, Goto-Inoue N, Setou M, Okita H, Fujimoto J, Ito C, Toshimori K, Kiyokawa N.
      GalNAcβ1,3-linked paragloboside carries the epitope of a sperm maturation-related glycoprotein that is recognized by the monoclonal antibody MC121. Biochem Biophys Res Commun. 2011 Mar 18; 406(3): 326-31.
    49. Zaima N, Goto-Inoue N, Adachi K, Setou M.
      Selective analysis of lipids by thin-layer chromatography blot matrix-assisted laser desorption/ionization imaging mass spectrometry. J Oleo Sci. 2011; 60(2):93-8.
    50. Setoguchi T, Kikuchi H, Yamamoto M, Baba M, Ohta M, Kamiya K, Tanaka T, Baba S, Goto-Inoue N, Setou M, Sasaki T, Mori H, Sugimura H, Konno H.
      Microarray analysis identifies versican and CD9 as potent prognostic markers in gastric gastrointestinal stromal tumors. Cancer Sci. 2011 Apr; 102(4):883-9.
    51. Valdes-Gonzalez T, Goto-Inoue N, Hirano W, Ishiyama H, Hayasaka T, Setou M, Taki T.
      New approach for glyco- and lipidomics–molecular scanning of human brain gangliosides by TLC-Blot and MALDI-QIT-TOF MS. J Neurochem. 2011 Mar;116(5):678-83.
    52. Shrivas K, Hayasaka T, Goto-Inoue N, Sugiura Y, Zaima N, Setou M.
      Ionic matrix for enhanced MALDI imaging mass spectrometry for identification of phospholipids in mouse liver and cerebellum tissue sections. Anal Chem. 2010 Nov 1; 82(21):8800-6.
    53. Goto-Inoue N*, Hayasaka T, Zaima N, Kashiwagi Y, Yamamoto M, Nakamoto M, Setou M.
      The detection of glycosphingolipids in brain tissue sections by imaging mass spectrometry using gold nanoparticles. J Am Soc Mass Spectrom. 2010 Nov; 21(11): 1940-3.
    54. Goto-Inoue N*, Hayasaka T, Setou M.
      Imaging mass spectrometry of glycolipids. Methods Enzymol. 2010; 478:287-301.
    55. Zaima N, Goto-Inoue N, Hayasaka T, Setou M.
      Application of imaging mass spectrometry for the analysis of Oryza sativa rice. Rapid Commun Mass Spectrom. 2010 Sep; 24(18):2723-9.
    56. Goto-Inoue N*, Setou M, Zaima N.
      Visualization of spatial distribution of gamma-aminobutyric acid in eggplant (Solanum melongena) by matrix-assisted laser desorption/ionization imaging mass spectrometry. Anal Sci. 2010;26(7):821-5.
    57. Hayasaka T, Goto-Inoue N, Zaima N, Shrivas K, Kashiwagi Y, Yamamoto M, Nakamoto M, Setou M.
      Imaging mass spectrometry with silver nanoparticles reveals the distribution of fatty acids in mouse retinal sections. J Am Soc Mass Spectrom. 2010 Aug; 21(8):1446-54.
    58. Setou M, Shrivas K, Sroyraya M, Yang H, Sugiura Y, Moribe J, Kondo A, Tsutsumi K, Kimura Y, Kurabe N, Hayasaka T, Goto-Inoue N, Zaima N, Ikegami K, Sobhon P, Konishi Y.
      Developments and applications of mass microscopy. Med Mol Morphol. 2010 Mar;43(1):1-5.
    59. Zaima N, Hayasaka T, Goto-Inoue N, Setou M.
      Matrix-assisted laser desorption/ionization imaging mass spectrometry. Int J Mol Sci. 2010; 11(12):5040-55.
    60. Morita Y, Ikegami K, Goto-Inoue N, Hayasaka T, Zaima N, Tanaka H, Uehara T, Setoguchi T, Sakaguchi T, Igarashi H, Sugimura H, Setou M, Konno H.
      Imaging mass spectrometry of gastric carcinoma in formalin-fixed paraffin-embedded tissue
      microarray. Cancer Sci. 2010 Jan;101(1):267-73.
    61. Harada T, Yuba-Kubo A, Sugiura Y, Zaima N, Hayasaka T, Goto-Inoue N, Wakui M, Suematsu M, Takeshita K, Ogawa K, Yoshida Y, Setou M.
      Visualization of volatile substances in different organelles with an atmospheric-pressure mass microscope. Anal Chem. 2009 Nov 1; 81(21):9153-7.
    62. Goto-Inoue N*, Hayasaka T, Taki T, Gonzalez TV, Setou M.
      A new lipidomics approach by thin-layer chromatography-blot-matrix-assisted laser desorption/ionization imaging mass spectrometry for analyzing detailed patterns of phospholipid molecular species. J Chromatogr A. 2009 Oct 16; 1216(42):7096-101.
    63. Hayasaka T, Goto-Inoue N, Zaima N, Kimura Y, Setou M.
      Organ-specific distributions of lysophosphatidylcholine and triacylglycerol in mouse embryo.
      Lipids. 2009 Sep;44(9):837-48.
    64. Zaima N, Hayasaka T, Goto-Inoue N, Setou M.
      Imaging of metabolites by MALDI mass spectrometry. J Oleo Sci. 2009; 58(8):415-9.
    65. Goto-Inoue N*, Hayasaka T, Zaima N, Setou M.
      The specific localization of seminolipid molecular species on mouse testis during testicular maturation revealed by imaging mass spectrometry. Glycobiology. 2009 Sep; 19(9):950-7.
    66. Taki T, Gonzalez TV, Goto-Inoue N, Hayasaka T, Setou M.
      TLC blot (far-eastern blot) and its applications. Methods Mol Biol. 2009; 536:545-56.
    67. Ageta H, Asai S, Sugiura Y, Goto-Inoue N, Zaima N, Setou M.
      Layer-specific sulfatide localization in rat hippocampus middle molecular layer is revealed by nanoparticle-assisted laser desorption/ionization imaging mass spectrometry. Med Mol Morphol. 2009 Mar; 42(1):16-23.
    68. Hayasaka T, Goto-Inoue N, Sugiura Y, Zaima N, Nakanishi H, Ohishi K, Nakanishi S, Naito T, Taguchi R, Setou M.
      Matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight (MALDI-QIT-TOF)-based imaging mass spectrometry reveals a layered distribution of phospholipid molecular species in the mouse retina. Rapid Commun Mass Spectrom. 2008 Nov; 22(21):3415-26.
    69. Goto-Inoue N, Hayasaka T, Sugiura Y, Taki T, Li YT, Matsumoto M, Setou M.
      High-sensitivity analysis of glycosphingolipids by matrix-assisted laser desorption/ionization
      quadrupole ion trap time-of-flight imaging mass spectrometry on transfer membranes. J
      Chromatogr B Analyt Technol Biomed Life Sci. 2008 Jul 1; 870(1):74-83.
    70. Kubota K, Sato Y, Suzuki Y, Goto-Inoue N, Toda T, Suzuki M, Hisanaga S, Suzuki A, Endo T.
      Analysis of glycopeptides using lectin affinity chromatography with MALDI-TOF mass spectrometry. Anal Chem. 2008 May 15; 80(10):3693-8.
    71. Nakamura K, Suzuki Y, Goto-Inoue N, Yoshida-Noro C, Suzuki A.
      Structural characterization of neutral glycosphingolipids by thin-layer chromatography coupled to matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight MS/MS. Anal Chem. 2006 Aug 15; 78(16):5736-43.
    72. Suzuki Y, Suzuki M, Ito E, Goto-Inoue N, Miseki K, Iida J, Yamazaki Y, Yamada M, Suzuki A.
      Convenient structural analysis of glycosphingolipids using MALDI-QIT-TOF mass spectrometry with increased laser power and cooling gas flow. J Biochem. 2006 Apr;139(4):771-7.